Progressive Retinal Atrophy (PRA)

by: By Karyn Colman, B.Vet.Med., MRCVS

According to Gelatt's Veterinary Ophthalmology (1999), PRA is a term for a group of hereditary diseases that are characterized by a degeneration or dysplasia (abnormal development) of the photoreceptors at the back of the eye. The changes are progressive and result in a loss of vision. All forms of PRA can be detected by trained Veterinary Ophthalmologists examining the back of the eye (once the visible changes are present), and incidences of PRA are included in the CERF statistics. A dog with PRA will not receive CERF certification. Electroretinograms (ERG) can detect changes in the function of the retina earlier than CERF examination can detect visible changes to the eye.

There are two main classifications of the disease processes involved in PRA:

  1. a primary effect on the photoreceptors (generalized PRA),

  2. abnormalities of the pigment epithelium behind the photoreceptors which causes secondary photoreceptor degeneration (central PRA or, more recently, RPED).


Central PRA is much less widespread in pure-bred dogs, apparently affecting Retrievers (Labrador and Golden) and Collie breeds almost exclusively. The progression of the disease is slower than GPRA and the dog may not become totally blind. This form of PRA has not, to date, been recorded in Alaskan Malamutes.

Generalized PRA is more widespread among the breeds and is a form of PRA that has been documented to affect the Alaskan Malamute in North America and in Europe. In generalized PRA the disease process usually leads to complete blindness. Generalized PRA is currently divided into two types of diseases:

  1. Early onset (retinal dysplasias),

  2. Later onset (prcd - progressive rod-cone degeneration).


The early onset retinal dysplasias result from abnormal development of the photoreceptors and breeds so affected can start to show signs as early as 12 weeks of age. For later onset prcd, clinical signs (or even eye changes) may not be seen until the dog is 4 years of age or older. Most frequently night blindness is the first clinical sign, but then as the condition progresses the dog shows decreased and, eventually, total loss of all vision. Owners may also notice that the dog has dilated pupils and an increase in the shininess at the back of the eye. Some dogs may also develop cataracts secondary to the PRA, seen as an increased cloudiness in the eye.

Since the ophthalmologic and clinical signs of Generalized PRA may not be detected until the dog is 4 years of age, or older, there have been considerable efforts made to find the gene(s) responsible for this condition, and with some success, in a number of breeds. Through genetic research it has been found that there are several different types of prcd with different genes and/or different mutations responsible in the different breeds. Thus a DNA test for PRA in one breed may not be helpful for PRA in another, even though the condition looks the same clinically. Since Malamutes have had a very small number of cases recorded, there is currently no impetus to develop a DNA test for Malamutes.


Known incidence of PRA in Malamutes:

North America: CERF has recorded 2 cases of Generalized PRA in Malamutes (up to end 1999),
Europe: Two cases of Generalized PRA have been recorded in Malamutes under the Swedish Kennel Club's official eye-testing scheme (up to end 2004).

The AMCA health survey conducted in 1996 by Jocelynn Jacobs-Knoll, DVM, recorded 3 cases of PRA and 4 cases of "Retinal Atrophy". This survey had respondents from USA, Canada and At Large (International).


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Offsite References

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PRA Today -
by Gregory M. Acland, B.V.Sc., D.A.C.V.O., M.R.C.V.S., Center for Canine Genetics & Reproduction, Cornell University
Current research in Progressive Retinal Atrophy, as well as detailed information of all aspects of this disease.   
prcd-PRA Test - Optigen
Describes the method of DNA testing for PRA, and includes information about the different forms of PRA
  prcd-PRA Test - More from Optigen
Describes the method and breeding strategies for the breeds for which DNA testing for prcd-PRA is currently available.
Progressive Retinal Atrophy - Canine Inherited Disorders Database
University of Prince Edward Island, Canada
Gives detailed information about the different types, diagnosis and breeding recommendations for affected dogs. Specifically mentions hemeralopia in the Alaskan Malamute.
Progressive Retinal Atrophy -
by Catherine Marley
Details the similarities and differences of PRA in different breeds.
  Progressive Retinal Atrophy - Veterinary Medical Database
by Julie Gionfriddo, DVM, AVCO Genetics Committee/CERF Liaison
Article from the Purdue University web site, dated June 1998.

 Please check our "Links" page for some personal web sites pertaining to this subject, and stories of affected dogs and their owners.